Possible algorithms for determining adverse reactions caused by food supplements in Romania

Introduction. The advertising of food supplements on various media channels or in specialty stores with natural products and other places, as well the lack informative educational programs for population upon side effects interaction drugs, have led to development uncontrolled marketing these products. 
 Material methods. PubMed, ResearchGate EUR-Lex databases were analyzed during 2015-2021, based search criteria on: adverse reactions, ingredient new food, supplements, algorithms. Results. Certain dietary can cause multiple effects, such as: impaired platelet function by decreased aggregation, gastrointestinal (diarrhea, vomiting), wound healing/epithelialization, bacterial fungal sepsis, most common patients older. Herbal resources Aloe vera, Matricaria recutita, Taraxacum officinale others, dermatological inhibit elimination drugs metabolised cytochrome P-450 (e.g. terbinafine). Allium sativum, Mentha piperita L. enzyme CYP2C9. Another a role metabolism which is inhibited plant CYP3A4.
 Conclusions. It imperative legislate reporting reactions caused including their drugs.